P2.02-035 PD-L1 IHC Test on Cytological Cell Block Specimen; Potential Utility and Practical Issues
نویسندگان
چکیده
منابع مشابه
Development of an Automated PD-L1 Immunohistochemistry (IHC) Assay for Non–Small Cell Lung Cancer
Nivolumab, a fully human IgG4 programmed death 1 (PD-1) immune checkpoint inhibitor antibody, developed by Bristol-Myers Squibb Inc., has activity across non-small cell lung cancer (NSCLC) histologies and is Food and Drug Administration approved for treatment of metastatic squamous NSCLC with progression on or after platinum-based chemotherapy. PD-L1 has been investigated as a potential biomark...
متن کاملPD-L1/PD-1: new kid on the “immune metabolic” block
Nowadays, reprogramming of the energy metabolism represents a well-established cancer hallmark. The debate regarding the functional rationale for energetic skewing towards aerobic glycolysis (i.e. the Warburg effect) as observed in various entities is still ongoing. Recent findings suggest the existence of heterocellular metabolic interactions that take place within the tumor microenvironment. ...
متن کاملClassifying Cancers Based on T-cell Infiltration and PD-L1.
Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus, the tumor has many strategies to evade an immune response. It has been proposed that four different types of tumor microenvironment exist based on the presence or absence of tumor-infiltr...
متن کاملCell-specific PD-L1 expression in DLBCL.
In this issue of Blood, a new study by Kiyasu et al used a double-staining technique to identify cell-specific programmed cell death ligand 1 (PD-L1) expression in 1253 diffuse large B-cell lymphoma (DLBCL) samples and analyzed the findings together with programmed death-1 (PD-1) expression in tumorinfiltrating lymphocytes (TILs) and clinical outcomes, providing new insights into the role of th...
متن کاملDiagnostic utility of Plasma Thromboplastin cell block preparation in cytological evaluation of serous effusions
Background: Cell block preparations act as a useful adjunct to smear cytology for categorization of malignant and benign effusions. Plasma thromboplastin cell block technique is simple, requires less time and offers improved cytomorphological features. Aim: To study the utility of Thromboplastin-plasma cell block technique and its diagnostic significance in conjunction with conventional cytolog...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2017
ISSN: 1556-0864
DOI: 10.1016/j.jtho.2017.09.1213